Coarse-grained normal mode analysis in structural biology
نویسندگان
چکیده
منابع مشابه
Coarse-grained normal mode analysis in structural biology.
The realization that experimentally observed functional motions of proteins can be predicted by coarse-grained normal mode analysis has renewed interest in applications to structural biology. Notable applications include the prediction of biologically relevant motions of proteins and supramolecular structures driven by their structure-encoded collective dynamics; the refinement of low-resolutio...
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The dynamic simulation of macromolecular systems with biologically relevant sizes and time scales is critical for understanding macromolecular function. In this context, normal mode analysis (NMA) approximates the complex dynamicalbehaviourofa macromoleculeas a simple setof harmonic oscillators vibrating around a given equilibrium conformation. This technique, originated from classical mechanic...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2005
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2005.08.007